Another difficult one to wholeheartedly recommend. I'm ultimately giving it thumbs-down because, while I did have fun, like many roguelikes I've played it overstayed its welcome with a loop that became repetitive long before the conclusion and not much to incentivize me getting there.
My obvious point of comparison is West of Dead, with which it shares the same isometric perspective, emphasis on fast, cover-based gunplay and, frankly, flaws. I will give D&N for being tighter and more responsive, owing to things such as the manual reload and a more flowing cover system, allowing the basic combat to feel twitchy and satisfying. In the long run, however, this is undermined by a poor loot game - most of the guns you'll find are so low-powered as to be worthless, even those in paid lootboxes, and if you happen to luck into a solid loadout chances are you'll go to near the end of the game before you find anything at all comparable. Even what's available back at the hub is rarely worth it, as their stats often heavily skewed or just too much of a drop compared to what you already have.
This is compounded by the severe lack in variety; again, it's better than WoD's singular objectives for each level, but you'll very quickly run out of new mission types, and most boil down to simply killing everything while getting to the end, although some - like defusing the bomb - clash with the game's mechanics so as to be no fun at all. The boss fights offer up a nice change in pace with their more puzzle-like structure, but having to beat each one three times with no real variation for the endgame gets old fast.
The procedurally-generated level design is also a bit problematic. While the four biomes are visually distinct and do a great job of exuding that cyberpunk western atmosphere, you'll quickly see the same basic patterns over and over, and there are some (the underground caves) that mesh poorly with the camera, resulting in areas where you can't see your character. This is to say nothing of some of the utterly random bugs I encountered, like an instance where I could walk (and shoot) through a wall as if it didn't exist, or enemies being placed in areas I couldn't reach.
Oh, and while WoD's plot was just as easily ignored, at least it made an effort to create some form of lore and backstory to its world. D&N's tongue-in-cheek sarcasm is good for a brief smirk, but nothing beyond that except background noise.
This is certainly worth playing at least a few hours for the enjoyment of the basic gameplay loop, but don't expect it to lead anywhere interesting, and certainly don't shell out full-price for it (the amount of content you're getting barely justifies it at 25% disccount). I'm probably judging this on an unfair scale considering it's an indie title that was obviously made with love and understanding of the genre, but there are certainly better options out there for roughly the same price, if not less.